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Information on the research we fund.

Centres of Excellence

Capacity building tomorrow’s leaders in cancer research to improve outcomes for cancer patients in Yorkshire This project will train and support a faculty of clinical and non-clinical researchers within the Yorkshire Cancer Research Fellowship Platform, with the aim of improving outcomes for Yorkshire’s cancer patients. Research will focus on themes such as living with cancer in Yorkshire, supporting patient’s choices, and development of new treatments. With backing from a multidisciplinary […]

Cervical Cancer Research

Cervical cancer screening in older women aged 55 – 64 years old Older women are less likely to attend cervical cancer screening appointments compared with younger women, but the reasons for this are not clear. Professor Una Macleod and her team will carry out in-depth interviews with patients aged 55-64 in Yorkshire to discover their views on cervical screening. Interviews with health professionals will also take place to determine attitudes […]

Childhood Cancer Research

Modelling Neuroblastoma initiation and progression using induced Pluripotent Stem Cells Childhood cancers, known as paediatric cancers, probably start to develop before birth. This project aims to create a model of the cells normally found in an embryo which may grow into these cancers. This will allow the team to investigate the earliest stages of paediatric cancer initiation, to pin point the defects that cause these cancers, and to test new […]

Clinical Trials

Administration of systemic oncolytic reovirus to patients with melanoma Certain viruses can both kill cancer cells directly and use a patient’s own immune system to fight their cancer. This project is investigating the use of a one of these viruses (reovirus) in patients with advanced melanoma. The virus will be given to patients before surgical treatment, and the cancerous tissue biopsies will be examined to see what effects the treatment […]

Clinical Trials Centre

Clinical trials are designed to test whether new drugs or treatment strategies are more effective than current treatments. They asses the side effects and impact of new treatments on patients day to day life as well as the beneficial effects on their symptoms. This often includes monitoring mental health in addition to physical health.     Clinical trials can also be designed to investigate ways of preventing cancer to reduce […]

Discovery Research

Genetic instability and death in cancer cells The integrity of the genetic information in cells is protected by elaborate mechanisms to ensure that an accurate DNA copy is passed from generation to generation. These mechanisms repair errors in DNA sequence or stop growth if DNA structure is compromised. If the level of DNA damage is too severe, cells may die rather than attempt repair. The purpose of this project is […]