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All Cancer Research

Cancer ResearchExamining the potential of PSMD9 to predict outcome to radiotherapy in cancer patients

Some patients respond better to radiotherapy than others. Predicting in advance which patients will not be responsive to radiotherapy will allow doctors to use higher doses of radiation, or drugs to increase the effectiveness of treatment. A group in Leeds have shown that a specific protein, PSMD9, predicts how well breast cancer patients respond to radiotherapy. This project examined whether this also applies in lung, rectal and prostate cancers.


  • Principal investigator: Dr Laura Smith & Dr Thomas Hughes
  • University of Leeds
  • Award amount: £35,000
  • April 2014 – April 2015



Cancer ResearchTIME4PallCare: Determining timely engagement with palliative care for patients with advanced cancer

Specialist palliative care services aim to relieve suffering and improve the quality of life for people with advanced diseases. Early access to these services can have benefits such as the improvement of symptoms and can give patients the chance to choose to die at home. However, in Leeds only 70% of cancer patients receive any palliative care, and those who do gain access receive it only six weeks before their death. This study aims to analyse the records of over 6,000 patients in order to establish the impact this pattern of referral has on quality of end of life care for cancer patients and identify the best time for a patient to be referred to these services.


  • Principal investigator: Dr Lucy Zeigler
  • University of Leeds
  • Award amount: £90,752
  • July 2015 – December 2016



Cancer ResearchUnderstanding and reducing inequalities for people with cancer: A programme of work based in Yorkshire

This research seeks to examine social inequalities in healthcare for people in Yorkshire by:
i) Understanding lung and head and neck cancer patients’ experiences from initially noticing a problem to being diagnosed;
ii) Investigating public understanding and views of cancer risks and symptoms;
iii) Examining the link between poverty, palliative care and place of death and examining referrals to and deaths in hospices;
iv) Adapting and testing a tool to assess the palliative care needs of people with cancer in the community;
v) Developing an intervention to prevent avoidable hospital re-admissions for patients with advanced cancer.


  • Principal applicant: Una Macleod
  • Hull York Medical School
  • Award amount: £749,828
  • October 2012 – September 2017



Cancer ResearchPatient non-attendance at GP urgent referral appointments for suspected cancer

Dr Knapp and his colleagues will be carrying out an investigation into why patients with suspected cancer do not attend urgent appointments. They will examine the reasons behind non-attendance, interviewing patients and GPs to establish their views on why this occurs, and compare the cancer outcomes of patients to discover how they are affected by non-attendance. The information will then be used to identify potential solutions to this problem in order to achieve earlier cancer diagnoses.


  • Principal investigator: Dr Peter Knapp
  • University of York
  • Award amount: £187,896
  • February 2016 – January 2018



Cancer ResearchCancer, Fertility and Me: The development and evaluation of a fertility preservation decision support intervention to support women with cancer in Yorkshire

Unfortunately, treatment for cancer often results in loss of fertility for female patients. Research has shown that women diagnosed with cancer in Yorkshire do not currently feel well supported in making decisions relating to their fertility, and many miss out on fertility care completely. This study will develop new tools to support women and help them to make an informed decision. By doing so the researchers hope to reduce the stress of this process and ensure that patients receive the services, information and care they need.


  • Principal investigator: Dr Georgina Jones
  • Leeds Beckett University
  • Award amount: £249,958
  • November 2015 – July 2018



Cancer ResearchAwareness and Beliefs About Cancer (ABACus): randomised controlled trial of the health check intervention to improve cancer symptom awareness and help seeking among people living in socioeconomically deprived communities

Research shows that cancer survival rates are lower in disadvantaged communities, possibly due to people not being aware of symptoms or putting off visiting the GP. Trained advisors working on this project will use an online health check questionnaire to help to raise awareness of cancer symptoms and cancer-related lifestyle risks in communities in Yorkshire and Wales, and encourage earlier help-seeking where appropriate. This project aims to increase earlier detection of cancer in deprived communities across Yorkshire, leading to a wider range of treatment options and a greater chance of survival.


  • Principal applicant: Dr Kate Brain
  • Cardiff University
  • Award amount: £486,014
  • May 2017 to September 2019



Cancer ResearchReducing inequalities in care for people with cancer and palliative care needs

When coping with terminal cancer, many people do not get access to the palliative care and support they need. This leads to an increase in hospital admissions and means some patients are not able to fulfill their wishes to remain at home. Professor Miriam Johnson and her team are helping to train GPs to identify and meet the palliative care requirements of cancer patients. This will reduce anxiety for these patients and their families and help to improve their quality of life.


  • Principal investigator: Professor Miriam Johnson
  • University of Hull
  • Award amount: £301,909
  • January 2016 – December 2020