Pim-1 chromatic modifier activity associated with myc-dependent gene expression
In cells, DNA is closely associated with a number of different proteins which help give it structure and stability. This complex of proteins and DNA is called chromatin. One way in which genes can be turned on and off is by rearranging the chromatin so that areas of DNA become exposed or hidden to certain molecules. PIM1 is a protein that affects chromatin structure, and is known to contribute to the development of aggressive lymphomas, and the major focus of this project was to determine how PIM1 helps to modify chromatin to promote cancer development.
- Principle investigator: Dr Pascal Lefevre
- University of Leeds
- Award amount: £53,525
- October 2011 – September 2014
Chemokine receptor targeted cancer therapies “
CXCR4 is a receptor protein relevant to early cancer diagnosis, providing information on disease progression and potential treatment options. Researchers at the University of Hull have developed new compounds which bind to CXCR4 and have properties which suggest they may be more effective therapies than current drugs which target these receptors.
- Principle investigator: Professor Stephen Archibald
- University of Hull
- Award amount: £123,312
- March 2014 – February 2016
Combining reovirus with current treatment modalities to potentiate cytotoxic and immune-mediated CLL therapy
Chronic Lymphocytic Leukaemia (CLL) is a common form of adult leukaemia which remains incurable. Researchers at the University of Leeds are investigating how to improve survival by using an existing treatment – Rituximab – alongside an anti-cancer virus. Rituximab works by labelling cancer cells so the immune system can recognise and kill them. The virus in question – called reovirus- only grows in cancer cells, and can both 1) lead to the cancer cells’ death and 2) stimulate immune cells to kill the cancer. By combining these two approaches, the researchers may be able to increase the proportion of cancer cells eliminated by the immune system.
- Principle investigator: Dr Fiona Errington-Mais
- University of Leeds
- Award amount: £197,087
- September 2013 – August 2016
- Last updated: 24/06/2016
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