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Childhood Cancer Research

Cancer ResearchModelling Neuroblastoma initiation and progression using induced Pluripotent Stem Cells

Childhood cancers, known as paediatric cancers, probably start to develop before birth. This project aims to create a model of the cells normally found in an embryo which may grow into these cancers. This will allow the team to investigate the earliest stages of paediatric cancer initiation, to pin point the defects that cause these cancers, and to test new approaches to diagnosis and treatment.

 

  • Principle investigator: Professor Peter Andrews
  • University of Sheffield
  • Award amount: £187,103 (Project Award)
  • January 2012 – January 2015

 

 

Cancer ResearchDevelopment of an anti-invasive therapeutic strategy for paediatric high grade gliomas

Paediatric high grade gliomas (pHGG) are aggressive brain tumours associated with poor outcomes. Tumour cells are capable of moving deeper into the brain, escaping surgical removal, and new treatments that block this invasion are needed. Some viruses can act as anti-cancer agents by attacking tumours; however, their effect in paediatric brain tumours is unknown. A team in Leeds will investigate the effects of an anti-cancer virus (HSV) on the invasive behaviour of paediatric high grade glioma cells. The team has shown that HSV may have therapeutic benefits, leading to improved outcomes.

 

  • Principle investigator: Dr Julia Cockle
  • University of Leeds
  • Award amount: £188,348
  • January 2013 – January 2016