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Head and Neck Cancer Research

Cancer ResearchThe role of T regulatory cells in the microenvironment of head and neck squamous cell carcinomas; relationship to prognosis and recurrence

Immune cells in the blood can recognise and kill tumour cells; however they often fail to do this successfully. This is partly due to the presence of a type of immune cell – T regulatory cells – which suppresses the tumour killing ability of other immune cells. The importance of the suppressive cells within the tumour tissue and their relationship to patient outcome is not fully understood. Therefore, this study aimed to clarify the role of these cells by looking more closely at their function within tumour tissue and how this relates to patient prognosis.

 

  • Principle investigator: Dr Victoria Green
  • University of Hull
  • Award amount: £53, 276
  • October 2011 – September 2014

 

 

Cancer ResearchMT-MMP expression in Head and Neck Cancer for Prodrug Development

Treatments for cancer need to be able to kill cancer cells whilst leaving healthy cells unaffected. A certain class of proteins, MT-MMPs, are at elevated levels in certain cancers of the head and neck. These proteins can be used to convert an inactive form of a drug into an active state. Given these proteins are elevated in cancer, the drug will only become activated in cancer cells. This project will identify exactly which MT-MMPs are elevated in cancer cells compared to normal cells. The results will inform the design of new prodrugs for future treatments.

 

  • Principle investigator: Professor Paul Loadman
  • University of Bradford
  • Award amount: £68,929
  • October 2013 – September 2016