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Prostate Cancer Research

Cancer ResearchProstate cancer develops in a small gland found in only men that helps in the production of semen. Prostate cancer is usually a slow progressing disease and can often go unnoticed until the tumour is large enough to put pressure on the urethra. Symptoms that can then occur are more frequent and urgent need to urinate, difficulty starting to urinate, weak flow of urine and feeling that your bladder has not fully emptied. It is usually diagnosed by blood tests, physical examination of the prostate and a biopsy.

 

 

Cancer ResearchA multidisciplinary approach to prostate cancer stem cells and therapy

By studying different cell types in prostate tumours, researchers at the University of York have found many of the genes responsible for resistance to treatment. They are now aiming to translate this knowledge into patient benefit by finding the best drug combinations to kill all of the tumour cells found in an advanced prostate cancer.

 

  • Principle investigator: Professor Norman Maitland
  • University of York
  • Award amount: £1,675,059
  • January 2012 to December 2015

 

 

Cancer ResearchCan we exploit microRNA expression patterns to improve the prognosis for prostate cancer patients?

The research of Professor Maitland and his team has shown that a small group of cells in every prostate cancer, the ‘cancer stem cells’, are responsible for the cancer’s spread and recurrence after treatment. They have also found that high levels of molecules known as microRNAs are produced by these cells. Professor Maitland is now studying microRNAs to discover if they can be used to develop improved treatments or tests to identify the most aggressive types of prostate cancer.

 

  • Principle investigator: Professor Norman Maitland
  • University of York
  • Award amount: £170,349
  • June 2014 to May 2017

 

 

Cancer ResearchUnravelling the mechanisms of bone metastasis as a pathway to improved therapies

Advanced breast and prostate cancers often spread to bone, and there are no effective therapies available to combat this. Professor Holen and her team have developed model systems which allow this process to be investigated and manipulated. Through use of these models they aim to establish how cancer cells colonise and grow in bone, and how drugs can be used to stop this from happening.

 

  • Principle investigator: Professor Ingunn Holen
  • University of Sheffield
  • Award amount: £71,703
  • October 2014 – September 2017

 

 

 
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